Program

PROGRAM

Monday 24th April

14.00-14.10           Introduction

14.10-14.50           Alexandre Bonvin. High-resolution, integrative modelling of biomolecular complexes from fuzzy data

14.50-15.30           Ozlem Keskin. Protein-protein interfaces: amino acid variations and hot spot residues

15.30-15.50           Sergei Grudinin. FFT-accelerated exhaustive flexible docking method

15.50-16.20           Coffee break

16.20-16.40           Sophie Sacquin-Mora. Great interactions: binding incorrect protein partners to learn about recognition and function

16.40-17.20           Yanay Ofran. "All models are wrong, some are useful": Predicting and designing interactions based on multiple wrong models

Tuesday 25th April

09.00-09.40           Rob Russell. Searching for mutations affecting protein interactions and how they relate to human diseases

09.40-10.20           Franca Fraternali. Protein Interaction Networks in Health and Disease

10.20-10.50           Coffee break

10.50-11.10           Yves Vandenbrouck. The quest for the missing proteins in the Human Proteome Project: the why and the how

11.10-11.30           Anna Niarakis. Protein-protein interactions: Cornerstones of cellular signaling cascades, in health and disease. The case of rheumatoid arthritis (RA).

11.30-12.10           Peter Uetz. Protein complexes and protein interaction networks in bacteria

12.10-14.30           Lunch and laptop presentations

14.30-15.10           Emmanuel Levy. Proteins evolve on the edge of supramolecular self-assembly

15.10-15.50           Julia Shifman. Cold spots in Protein Binding

15.50-16.10           Frederic Cazals. The Structural Bioinformatics Library

16.10-16.40           Coffee Break

16.40-17.20           Monika Fuxreiter. Dynamic interactions and fuzziness in protein complexes and higher-order assemblies

17.20-17.40          Alessandro Barducci. Modeling Hsp70/Hsp40 interaction by multiscale molecular simulations and co-evolutionary sequence analysis 

19.00                     Conference dinner at "Brasserie Argenson", 40 allée Pierre de Coubertin

Wednesday 26th April

09.00-09.40           Raphael Guerois. Structural modeling and design of protein interactions using evolution

09.40-10.00           Annick Dejaegere. Unusual dimerization within a protein family having conserved architecture: the glucocorticoid nuclear receptor

10.00-10.20           Elodie Laine. Towards a large-scale prediction of protein partners

10.20-10.40           Coffee break

10.40-11.00           Anne Lopes. Studying conservation of interaction energy landscapes across structural homologs through cross-docking calculations

11.00-11.40           Elisa Fadda. Are structure-less protein regions really so structure-less? An atomistic view of the architecture of disorder and its functions in protein-protein interactions

11.40-12.20           Patrick Aloy. A network biology approach to novel therapeutic strategies