Despite progress with experimental high-throughput techniques for the analysis of protein-protein interactions, bioinformatics, molecular modeling and simulation can play important roles in determining the stability and the structure of protein complexes, in identifying weak transient interactions, in understanding the role of non-functional interactions in a crowed molecular environment and in analyzing dynamic protein interaction networks.
Molecular biology, biochemistry, genetics, bioinformatics and molecular simulation all have important roles to play in understanding the complex protein networks that populate living matter. These networks in turn rely on protein-protein interactions that are characterized by structures, stabilities and lifetimes that vary over wide ranges and take place in a complex, heterogeneous and crowed environment.
The aim of the meeting is to provide an overview of protein-protein interactions, covering a range of scales: from physico-chemical analysis to prediction, from binary complexes to large assemblies, from cellular organization to the comparison of different organisms and from function to dysfunction and potential therapies.
Patrick ALOY Institute for Research in Biomedicine, Spain
Alexandre BONVIN Utrecht University, Holland
Elisa FADDA Maynooth University, Ireland
Franca FRATERNALI King's College London, UK
Monika FUXREITER University of Debrecen, Hungary
Raphaël GUEROIS Institute of Integrative Biology of the Cell, CEA, France
Ozlem KESKIN Koç University, Turkey
Emmanuel LEVY Weizmann Institute of Science, Israel
Yanay OFRAN Bar-Ilan University, Israel
Rob RUSSELL University of Heidelberg, Germany
Julia SHIFMAN Hebrew University of Jerusalem, Israel
Peter UETZ Virginia Commonwealth University, USA
Ilya VAKSER University of Kansas, USA
Richard LAVERY IBCP, CNRS / University of Lyon
Juliette MARTIN IBCP, CNRS / University of Lyon
Alessandra CARBONE LCQB, CNRS / University P. et M. Curie, Paris
Sophie SACQUIN-MORA IBPC, CNRS Paris
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